{"id":3970,"date":"2020-09-29T15:37:30","date_gmt":"2020-09-29T13:37:30","guid":{"rendered":"https:\/\/www.ab-science.com\/science\/"},"modified":"2026-10-05T11:56:00","modified_gmt":"2026-10-05T09:56:00","slug":"science","status":"publish","type":"page","link":"https:\/\/www.ab-science.com\/fr\/science\/","title":{"rendered":"Science"},"content":{"rendered":"

[vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb el_class=\u00a0\u00bbabp-section abp-section–intro\u00a0\u00bb][vc_column][vc_column_text]<\/p>\n

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Science<\/p>\n

Comprendre nos approches scientifiques<\/h2>\n
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AB Science est une entreprise qui con\u00e7oit et d\u00e9veloppe de nouveaux m\u00e9dicaments dans le domaine des prot\u00e9ines kinases, enzymes cl\u00e9s des voies de signalisation intracellulaire dont la surexpression ou les mutations peuvent notamment conduire \u00e0 des pathologies tumorales ou neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n

Notre science est bas\u00e9e sur des r\u00e9seaux de recherche priv\u00e9s et acad\u00e9miques compos\u00e9s de scientifiques de renomm\u00e9e internationale dans les domaines de la chimie de la pharmacologie et de la m\u00e9decine.<\/p>\n

Le masitinib, la mol\u00e9cule phare d\u2019AB Science est un inhibiteur de tyrosine kinases contr\u00f4lant l\u2019activation inappropri\u00e9e des mastocytes et des cellules gliales, cellules impliqu\u00e9es dans les processus tumoraux, inflammatoires et neuro-immunitaires.<\/p>\n

AB Science d\u00e9veloppe \u00e9galement une nouvelle mol\u00e9cule d\u00e9stabilisant la tubuline et inhibant les ALDHs, enzymes impliqu\u00e9es dans la survie des cellules souches tumorales. Cette mol\u00e9cule cod\u00e9e AB8939, est actuellement en essai clinique de phase 1 dans les leuc\u00e9mies my\u00e9lo\u00efdes aigu\u00ebs r\u00e9fractaires.<\/p>\n<\/div>\n<\/div>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb el_class=\u00a0\u00bbabp-section abp-section–soft\u00a0\u00bb][vc_column][vc_column_text]<\/p>\n

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Approches scientifiques<\/p>\n

Explorer les programmes par domaine<\/h2>\n

Trois liens directs donnent acc\u00e8s aux m\u00e9canismes d’action par indication.<\/p>\n

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Masitinib<\/span><\/p>\n

Masitinib dans les troubles neurod\u00e9g\u00e9n\u00e9ratifs<\/h3>\n

Scl\u00e9rose lat\u00e9rale amyotrophique, scl\u00e9rose en plaques et maladie d\u2019Alzheimer.<\/p>\n

D\u00e9couvrir l\u2019approche \u2192<\/a><\/p>\n<\/div>\n

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Masitinib<\/span><\/p>\n

Masitinib dans la dr\u00e9panocytose<\/h3>\n

Comprendre l\u2019approche d\u00e9velopp\u00e9e dans cette maladie h\u00e9matologique.<\/p>\n

D\u00e9couvrir l\u2019approche \u2192<\/a><\/p>\n<\/div>\n

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AB8939<\/span><\/p>\n

AB8939 en oncologie<\/h3>\n

Une mol\u00e9cule synth\u00e9tique d\u00e9stabilisatrice de microtubules en cours de d\u00e9veloppement dans la leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb.<\/p>\n

D\u00e9couvrir l\u2019approche \u2192<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb el_class=\u00a0\u00bbabp-section abp-section–intro\u00a0\u00bb][vc_column][vc_column_text] Science Comprendre nos approches scientifiques AB Science est une entreprise qui con\u00e7oit et d\u00e9veloppe de nouveaux m\u00e9dicaments dans le domaine des prot\u00e9ines kinases, enzymes cl\u00e9s des voies de signalisation intracellulaire dont la surexpression ou les mutations peuvent notamment conduire \u00e0 des pathologies tumorales ou neurod\u00e9g\u00e9n\u00e9ratives. Notre science est bas\u00e9e sur des…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3970","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nScience – AB Science<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ab-science.com\/fr\/science\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Science\" \/>\n<meta property=\"og:description\" content=\"[vc_row full_width=\u00a0\u00bbstretch_row\u00a0\u00bb el_class=\u00a0\u00bbabp-section abp-section–intro\u00a0\u00bb][vc_column][vc_column_text] Science Comprendre nos approches scientifiques AB Science est une entreprise qui con\u00e7oit et d\u00e9veloppe de nouveaux m\u00e9dicaments dans le domaine des prot\u00e9ines kinases, enzymes cl\u00e9s des voies de signalisation intracellulaire dont la surexpression ou les mutations peuvent notamment conduire \u00e0 des pathologies tumorales ou neurod\u00e9g\u00e9n\u00e9ratives. 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