{"id":10866,"date":"2026-07-31T13:38:41","date_gmt":"2026-07-31T11:38:41","guid":{"rendered":"https:\/\/www.ab-science.com\/?page_id=10866"},"modified":"2026-07-31T13:48:38","modified_gmt":"2026-07-31T11:48:38","slug":"masitinib-drepanocytose","status":"publish","type":"page","link":"https:\/\/www.ab-science.com\/fr\/science\/masitinib-drepanocytose\/","title":{"rendered":"Masitinib dans la dr\u00e9panocytose"},"content":{"rendered":"

[vc_row][vc_column][vc_single_image image=\u00a0\u00bb10867″ img_size=\u00a0\u00bbfull\u00a0\u00bb][vc_row_inner][vc_column_inner][vc_column_text]La dr\u00e9panocytose est une maladie h\u00e9r\u00e9ditaire qui se manifeste par un trouble des globules rouges. Le masitinib est d\u00e9velopp\u00e9 pour traiter les formes les plus s\u00e9v\u00e8res de la maladie, qui repr\u00e9sentent environ 65 % des cas de dr\u00e9panocytose. Les formes graves de la maladie repr\u00e9sentent un d\u00e9fi majeur pour la sant\u00e9 publique et peuvent mener au d\u00e9c\u00e8s pr\u00e9coce. Le traitement de la dr\u00e9panocytose peut \u00eatre curatif gr\u00e2ce \u00e0 la th\u00e9rapie g\u00e9nique (qui cible la mutation HbS), mais cette option reste extr\u00eamement limit\u00e9e en raison de la raret\u00e9 des donneurs, des probl\u00e8mes de tol\u00e9rance non r\u00e9solus et des co\u00fbts tr\u00e8s \u00e9lev\u00e9s. Le traitement standard de la dr\u00e9panocytose est une transfusion de globules rouges ainsi qu\u2019un traitement \u00e0 l’hydroxyur\u00e9e pour g\u00e9rer les complications, mais le besoin m\u00e9dical reste important.[\/vc_column_text]

<\/span>M\u00e9canisme d'action du masitinib dans la dr\u00e9panocytose<\/span><\/div><\/div>
<\/div>[vc_column_text]R\u00e9cemment, un r\u00f4le majeur de l’inflammation m\u00e9di\u00e9e par les cellules immunitaires inn\u00e9es et favorisant la vaso-occlusion a \u00e9t\u00e9 mis en \u00e9vidence. Des observations cliniques et nos travaux exp\u00e9rimentaux chez la souris et permis de mettre en \u00e9vidence le r\u00f4le des mastocytes et des basophiles dans les complications associ\u00e9es \u00e0 la dr\u00e9panocytose\u00a0:<\/p>\n
    \n
  • Le degr\u00e9 d’activation des mastocytes chez les patients atteints de dr\u00e9panocytose pourrait participer \u00e0 l’h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 de l’inflammation et des complications chroniques et aigu\u00ebs.<\/li>\n
  • Le r\u00f4le potentiel des basophiles dans la dr\u00e9panocytose n’a jamais \u00e9t\u00e9 \u00e9tudi\u00e9, mais compte tenu de leur r\u00f4le dans diverses maladies et de leur capacit\u00e9 \u00e0 lib\u00e9rer de la substance-P et de l’histamine, ils pourraient \u00e9galement \u00eatre des acteurs importants de la physiopathologie de la dr\u00e9panocytose.<\/li>\n<\/ul>\n

    Le masitinib est un inhibiteur de KIT, LYN et FYN, trois kinases majeures impliqu\u00e9es dans l’activation des mastocytes et des basophiles.[\/vc_column_text]

    <\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

    [vc_row][vc_column][vc_single_image image=\u00a0\u00bb10867″ img_size=\u00a0\u00bbfull\u00a0\u00bb][vc_row_inner][vc_column_inner][vc_column_text]La dr\u00e9panocytose est une maladie h\u00e9r\u00e9ditaire qui se manifeste par un trouble des globules rouges. Le masitinib est d\u00e9velopp\u00e9 pour traiter les formes les plus s\u00e9v\u00e8res de la maladie, qui repr\u00e9sentent environ 65 % des cas de dr\u00e9panocytose. Les formes graves de la maladie repr\u00e9sentent un d\u00e9fi majeur pour la sant\u00e9 publique et…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3970,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10866","page","type-page","status-publish","hentry","description-off"],"yoast_head":"\nMasitinib dans la dr\u00e9panocytose | AB Science<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez le d\u00e9veloppement du masitinib dans les formes s\u00e9v\u00e8res de dr\u00e9panocytose et son action ciblant les mastocytes et les basophiles.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ab-science.com\/fr\/science\/masitinib-drepanocytose\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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